 Sildenafil was originally discovered by a group of Chemists in search of a treatment for hypertension and angina. During clinical trials it was discovered Sildenafil did not work well for angina, however it did effectuate noticeable penile erections. The huge drug company, Pfizer, patented the drug in 1996. The drug was quickly approved as an oral treatment for erectile dysfunction by the Food and Drug Administration and was being sold in the United States as Viagra by 1998. Sales of the drug between 1999 and 2001 were over a billion dollars annually.
 A generic Viagra drug is the chemical equivalent of a drug with an expired patent. Once the patent expires, pharmaceutical companies are allowed to produce the same active chemical compound. Sometimes the pharmaceutical company is able to produce the compound at a lesser cost than the originating drug company. Other times demand decreases as supply increases making a winning situation for the consumer. Generic Viagra drugs if approved by the FDA are as safe and effective as the brand name product.
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And What About
 In an effort to overturn Pfizer's exclusive patent, Eli Lilly and Icos Corporation filed a case against Pfizer in November of 2000 in a High Court in London . The court ruled the 1993 patent on the main ingredient of the drug was invalid. Pfizer appealed the court's ruling; however it was upheld by the Court of Appeal in 2002. In 2003 two new drugs Levitra and Cialis became available in Europe and other countries for the treatment of erectile dysfunction.
How Erectile Dysfunction Medications
Viagra, Levitra and Cialis work by prolonging smooth muscle relaxation causing erection and widening, and improve blood flow to the erection chambers within the penis and pelvic area. They work identically as inhibitors of the specific enzyme known as type 5 phosphodiesterase, which occur in the arteries that supply blood to the penis. These drugs enhance erection but do not increase libido. To work, there must be sexual stimulation, in the absence of sexual stimulation there will not be any erection. These drugs do not cause mood alteration. All three report improvement in achieving and maintaining erection in 80% of the men who use the product.
The
 While all three drugs effectively treat erectile dysfunction, Viagra absorption is moderately impaired after eating a meal high in fat, reducing the peak effect. Cialis and Levitra can be taken without any concern of food or alcohol lessoning the products ability to work. While Viagra and Levitra only work 4 to 6 hours, they are better for men who take nitrates for angina, since nitrates are contraindicated for 24 hours after taking erectile dysfunction mediations.
After 10 years and hundreds of millions of dollars, Cialis was developed by Eli Lily and Company in 2003, as a generic equivalent of Viagra . The drugs active ingredient is tadalafil. It has come to be known as "the weekend pill" because it generally lasts for 36 hours. This is a huge benefit for men desiring to have sex more than once in a 36 hour period
 Longevity is also a great advantage to women as it generally takes women longer to achieve climax than men. Elizabeth Rae Larson, co-founder and director of the Seattle Institute for Sex Therapy, Education and Research, has dealt with Viagra users who became obsessed with trying to perform within the 4 to 6 hour window. Cialis gives users greater flexibility, and confidence they will be ready when the opportunity presents itself.
Levitra, another generic Viagra , was developed by Bayer and GlaxoSmithKline and was launched in the US in 2003. Studies show Levitra to have some benefits over Viagra and Cialis. In studies men who suffer with diabetes respond better to this drug. Men who take Viagra sometimes suffer temporary vision problems but Levitra users rarely if ever suffer this side effect. Studies have shown a slightly faster activation and the cost is slightly less than Viagra.
Which One
 With the Food and Drug Administration requiring strict testing to determine a drugs safety, price becomes the greatest difference between brand and generic Viagra drugs. Cialis and Levitra are as safe and effective as Viagra, all three share in their ability to give a man confidence, lesson depression caused by erectile dysfunction, and improve sexual relations resulting from erection and stamina but cost less giving consumers choice, and value. The one to choose is the one that best fits the user's life style and medical needs.
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